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Preventing and managing chronic conditions

Chronic disease is the leading cause of death in India, and our research program looks to address this rise in conditions such as cardiovascular disease, diabetes and stroke.

Our aim is to make a significant contribution towards improving the health landscape in India, by better understanding important causes of illness and death and their prevention.

Our current projects

Four in one polypill: the use of a multidrug pill in reducing cardiovascular events The UMPIRE project aims to investigate a polypill strategy, by testing adherence compared to usual care in patients at high-risk of cardiovascular events.

Support for cardiovascular disease prevention in primary healthcare A feasibility study of a simple tool for health workers to evaluate cardiovascular disease risk in patients. The system also provides prevention advice, and has been developed for use at primary healthcare centres in low and middle-income countries. 

ADVANCE: the world’s largest study of treatments for type 2 diabetes Following the release of the results from the ADVANCE study, ADVANCE ON will provide important information about the potential long-term effects of  blood pressure lowering and glucose control on vascular outcomes in patients with type 2 diabetes.

Prevention of type 2 diabetes in women with gestational diabetes in urban India – This study aims to evaluate the effectiveness of a lifestyle intervention for the prevention of type 2 diabetes in women with gestational diabetes in India

Investigating sleep apnea and cardiovascular disease – The SAVE trial will determine the effects of nasal continuous positive airway pressure (CPAP) in preventing cardiovascular disease in high risk patients with moderate-severe obstructive sleep apnea.

Improving chances of recovery after stroke – The landmark INTERACT project is studying the effects of blood pressure lowering following a stroke.