01402nas a2200229   4500000000100000008004100001100001300042700002000055700001300075700001100088700001200099700001200111700001300123700001200136700001300148245010200161250001500263300001000278490000700288520082600295020005101121       2015                            d1 aKohli H.1 aRamachandran R.1 aGupta K.1 aJha V.1 aNada R.1 aKumar V1 aKumar A.1 aSuri D.1 aGupta A.00aAntibodies to m-type phospholipase A2 receptor in children with idiopathic membranous nephropathy  a2015/07/22  a572-50 v203 a<p>
Idiopathic membranous nephropathy (IMN), the commonest cause of adult nephrotic syndrome (NS), accounts for only a minority of paediatric NS. Antibodies to m-type phospholipase A2 receptor (PLA2R) are seen in two-thirds of adult IMN cases. PLA2R staining in glomerular deposits is observed in 74% and 45% of adult and paediatric IMN cases, respectively. However, there are no reports of anti-PLA2R in paediatric IMN. We evaluated anti-PLA2R levels and PLA2R in gloemrular deposits in paediatric IMN seen at our center. Five cases were enrolled, all the cases stained for PLA2R in glomeruli and three (60%) had antibodies to PLA2R antigen. There was a parellel reduction in proteinuria and anti-PLA2R titer. The present report suggests that PLA2R has a contributory role in the pathogenesis of paediatric IMN.
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