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Indian chronic kidney disease study: Design and methods.

TitleIndian chronic kidney disease study: Design and methods.
Publication TypeJournal Article
Year of Publication2017
AuthorsKumar, V, Yadav, AKumar, Gang, S, John, O, Modi, GK, Ojha, JPrakash, Pandey, R, Parameswaran, S, Prasad, N, Sahay, M, Varughese, S, Baid-Agarwal, S, Jha, V
JournalNephrology (Carlton)
Volume22
Issue4
Pagination273-278
Date Published04/2017
ISSN1440-1797
KeywordsAdolescent, Adult, Aged, Biological Specimen Banks, biomarkers, Cardiovascular Diseases, Disease Progression, Female, Genetic Predisposition to Disease, Glomerular Filtration Rate, Humans, India, Kidney, Kidney Failure, Chronic, Male, Middle Aged, Prognosis, Prospective Studies, Renal Insufficiency, Chronic, Renal Replacement Therapy, Research Design, Risk Factors, Severity of Illness Index, Time Factors, Young Adult
Abstract

AIM: The rate and factors that influence progression of chronic kidney disease (CKD) in developing countries like India are unknown. A pan-country prospective, observational cohort study is needed to address these knowledge gaps.

METHODS: The Indian Chronic Kidney Disease (ICKD) study will be a cohort study of approximately 5000 patients with mild to moderate CKD presenting to centres that represent different geographical regions in India. Time to 50% decline in baseline estimated glomerular filtration rate, need of renal replacement therapy or any new cardiovascular disease (CVD) event or death from CVD are the primary end points.

VALUE OF STUDY: This study will provide the opportunity to determine risk factors for CKD progression and development of CVD in Indian subjects and perform international comparisons to determine ethnic and geographical differences. A bio-repository will provide a chance to discover biomarkers and explore genetic risk factors.

DOI10.1111/nep.12789
Alternate JournalNephrology (Carlton)
PubMed ID27062078
English